When meditation and all else fails,  thinq on. If the results are disappointing, maybe you are expecting too much. Maybe your audience is too bashful to reply. Or maybe they're not interested in your problems because they have more important problems of their own.

It's not good to be alone.

Thank you Ted for posing this key question. My first response is to think of the things that cause me to sometimes lose interest in living. In no special order they are: depression, mental fatigue and dullness, repetition, the fact that I have satisfied my curiosity about most things that once intrigued me, the fact that more and more people find me not very interesting, the awareness that, given my age, in 10, 20, 30 years I will die just as many have died before me.

I don't quite understand your allusions to entropy. I have googled "entropy" to refresh my memory. A see a reference to "the arrow of time." And an explanation by Dave Slavin, a teacher in Saginaw, that is helpful.

It may be that entropy - as physics or as metaphor (or perhaps as both) is what is bothering you, but for me it is more these things I have listed above and the way they affect my eager but depressive temperament. 

I've always had too many interests and not much ability to stick with any paradigm for long. I tend to outgrow paradigms after a few years, whether I want to outgrow them or not. Having outgrown so many, I am at this point in time (riding as I am the arrow of time) skeptical of all paradigms.

For instance for the first 40 years of my life, it seemed very important to always be learning and increasing my understanding as much as I could. I placed great value on the search for Truth, even recognizing as I did that whatever Truth I found would be approximate at best. This quest for Truth was a paradigm that organized my experience.

But it doesn't compel me the way it used to do. Maybe I am just too distracted to keep my eye on the goal of wisdom.

Here is my list of things that give me energy, even as heat finds more and more ways to leak out of my body: talking with children and young people, observing the astonishing technological changes in the world and their impact on history, finding out what has become of people I knew long ago, exerting myself to get some physical exercise, taking pictures (hobby for this stage of life) and looking at photographs, talking at length with other thoughtful people about the amazing beauty and complexity of being alive and human, actually being of use to a few other people through work and personal relationships.