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How to follow one's vocation if it meant letting down you family?
I have been thinking pretty hard whether to write what is following below. After reading several threads I came to the conclusion that I should indeed do so.

What would you do if you knew what your vocation was but in pursuing this career you would be letting down your family big time?

A very good friend of mine is a talented physicist. She is acing every exam and is loved by all her professors. Her dream is to become a professor or at least a good researcher herself. She is just completing her masters degree and thus still has to do her PhD followed up by several post-doc positions in order to achieve her goal.

Unfortunately her family has never been rich and to aggravate things even more her father had an accident and is now disabled. Their house is still not paid for and the bank has already expressed that they will be thrown out if they are not able to pay the agreed upon installments. Her father has spent 25 years of his life building and paying for this house.

You might begin to see where this is going already. She could drop out of the university in order to work for a consulting enterprise. The salary would be high enough to solve the financial problems besetting the family. Still this would certainly kill any chance of her ever achieving or coming close to her dream. I have talked and listened to her at length but I could not come up with any solution or viable alternative. Sometimes life is really a bitch and so often it hits those who deserve better and have the abilities to achieve great things.

Her siblings and parents would  manage if she were to pursue a career in academics. But it would still mean losing their home and moving into a cheap rented apartment. What is more she knows that there is no guarantee that she will achieve what she wants. The academic world is fraught with talented people who were eventually forced to go into the free economy.
Your friend is in a tough place - she is in Germany where education is so linear that taking a few years off is impossible.  I imagine she is in her twenties, and in the thought of throwing away her life like this must seem like a deep black hole.
There are many factors playing into this, and it's true that one way or another her life will take a particular direction from this decision.  Her dreams are not forever closed to her though.  Perhaps not in Germany, but in many places in the world, having worked in the "free economy" is not an obstacle to re-entering the academic world.

In response to rhea nödel
"Perhaps not in Germany, but in many places in the world, having worked in the "free economy" is not an obstacle to re-entering the academic world."
You are right but I don't think there is any way she could go back to doing physics after working as consultant for several years.
It is unfortunate but I understand how she feels. What good will it do her to achieve her dream knowing that she did so by
forsaking her family in a moment of dire need.

Today she called me to tell me that she did accept an offer from the BCG (Boston Consulting Group). I already expected that when posting yesterday. Still writing about
the whole situation helped me to cope with it. She is a dear friend, a great scientist and an awesome person who loves philosophy and has a great taste when it comes to books. I know people working at the BCG and I know that this enterprise is going to drain her. Consulting enterprises are like juice squeezers – they lure young and clever people with high salaries and perks in order to work them like slaves and discard them when the burns out syndromes start kicking in.  
Juri, a friend of mine who studied physics and whom I thought had a chance to get a Nobel prize some day (she was really brilliant) also quit for consulting though at a much later stage, after a Ph.D. at Harvard and a postdoc somewhere. I lost contact with her a long time before so I don't know the details. I think it was because she wanted a family, or something like that. (I know she was heavily sought after for postdoc but I didn't think she made a good choice of where to go so that might have influenced the outcome). That is, in her case letting down the family was perhaps letting down creating a family.

Another reason I spoke of my friend was to say that even if your friend continued who knows what the future would bring and she would have such heavy guilt on herself that there was nothing she could do besides take the consulting job - an awful job to take for anything besides money, I agree, but sometimes one really needs money.

I'll mention the following related topic of: should we act by what is best for ourselves or by what is best for society? where society includes parents etc.

There is a nice proverb which says: people make plans and god laughs.
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